CCHCR1 Human Gene Knockout Kit (CRISPR)

CAT#: KN222150LP

CCHCR1 - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
• Donor DNA: Luciferase-Puro
• Symbol: CCHCR1
• Locus ID: 54535
• Components:

  KN222150G1, CCHCR1 gRNA vector 1 in pCas-Guide CRISPR vector

  KN222150G2, CCHCR1 gRNA vector 2 in pCas-Guide CRISPR vector

  KN222150LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001105563, NM_001105564, NM_019052
• UniProt ID: Q8TD31
• Synonyms: C6orf18; HCR; SBP
• Summary: This gene encodes a protein with five coiled-coil alpha-helical rod domains that is thought to act as a regulator of mRNA metabolism through its interaction with mRNA-decapping protein 4. It localizes to P-bodies, the site of mRNA metabolism, with an N-terminus that is required for this subcellular localization, suggesting it is a P-body component. Naturally occurring mutations in this gene are associated with psoriasis. [provided by RefSeq, May 2017]