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SHP2 (PTPN11) Human Gene Knockout Kit (CRISPR)

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SKU
KN220029BN
PTPN11 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "SHP2 or NM_002834"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol SHP2
Locus ID 5781
Components

KN220029G1, SHP2 gRNA vector 1 in pCas-Guide CRISPR vector

KN220029G2, SHP2 gRNA vector 2 in pCas-Guide CRISPR vector

KN220029BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_002834, NM_080601, NM_001330437
UniProt ID Q06124
Synonyms BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. provided by RefSeq, Aug 2016
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Documents
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Other Versions
SKU Description Size Price
GA103926 PTPN11 CRISPRa kit - CRISPR gene activation of human protein tyrosine phosphatase non-receptor type 11 1 kit
$1,657.00
KN220029 PTPN11 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN220029LP PTPN11 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN220029RB PTPN11 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN420029 PTPN11 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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