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DNMT1 Human Gene Knockout Kit (CRISPR)

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SKU
KN217851LP
DNMT1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "DNMT1 or NM_001130823"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol DNMT1
Locus ID 1786
Components

KN217851G1, DNMT1 gRNA vector 1 in pCas-Guide CRISPR vector

KN217851G2, DNMT1 gRNA vector 2 in pCas-Guide CRISPR vector

KN217851LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001130823, NM_001318730, NM_001318731, NM_001379
UniProt ID P26358
Synonyms ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI; MCMT
Summary This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jan 2016
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Other Versions
SKU Description Size Price
GA101242 DNMT1 CRISPRa kit - CRISPR gene activation of human DNA methyltransferase 1 1 kit
$1,657.00
KN217851 DNMT1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN217851BN DNMT1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN217851RB DNMT1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN417851 DNMT1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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