CARD14 Human Gene Knockout Kit (CRISPR)

CAT#: KN217455LP

CARD14 - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
• Donor DNA: Luciferase-Puro
• Symbol: CARD14
• Locus ID: 79092
• Components:

  KN217455G1, CARD14 gRNA vector 1 in pCas-Guide CRISPR vector

  KN217455G2, CARD14 gRNA vector 2 in pCas-Guide CRISPR vector

  KN217455LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001257970, NM_024110, NM_052819, NR_047566, NM_001366385
• UniProt ID: Q9BXL6
• Synonyms: BIMP2; CARMA2; PRP; PSORS2; PSS1
• Summary: This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]