NLRC5 Human Gene Knockout Kit (CRISPR)

SKU KN214810BN

NLRC5 - human gene knockout kit via CRISPR, HDR mediated

Product Data

• Format: 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
• Vector: mBFP-Neo
• Target Symbol: NLRC5
• Locus ID: 84166
• Components:

  KN214810G1, NLRC5 gRNA vector 1 in pCas-Guide CRISPR vector

  KN214810G2, NLRC5 gRNA vector 2 in pCas-Guide CRISPR vector

  KN214810BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001330552, NM_032206
• UniProt ID: Q86WI3
• Synonyms: CLR16.1; NOD4; NOD27
• Summary: This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]
• Shipping: Ambient