YAP1 Human Gene Knockout Kit (CRISPR)

CAT#: KN214393RB

YAP1 - human gene knockout kit via CRISPR, HDR mediated



HDR-mediated knockout kit validation

  See Other Versions

USD 1,657.00

4 Weeks*

Size
    • 1 kit

Product Images

Frequently bought together (3)
pCAS-Scramble, pCas-Guide vector with a scrambled sequence as a negative control (10 µg)
    • 10 ug

USD 450.00


Mouse Monoclonal YAP1 Antibody (1A12)
    • 100 ul

USD 478.00


YAP1 (Myc-DDK-tagged)-Human Yes-associated protein 1 (YAP1), transcript variant 3
    • 10 ug

USD 686.00

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Specifications

Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Donor DNA RFP-BSD
Symbol YAP1
Locus ID 10413
Components

KN214393G1, YAP1 gRNA vector 1 in pCas-Guide CRISPR vector

KN214393G2, YAP1 gRNA vector 2 in pCas-Guide CRISPR vector

KN214393RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001130145, NM_001195044, NM_001195045, NM_001282097, NM_001282098, NM_001282099, NM_001282100, NM_001282101, NM_006106
UniProt ID P46937
Synonyms COB1; YAP; YAP2; YAP65; YKI
Summary This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]

Other Versions

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.