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Hamartin (TSC1) Human Gene Knockout Kit (CRISPR)

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SKU
KN213332RB
TSC1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "Hamartin or NM_000368"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol Hamartin
Locus ID 7248
Components

KN213332G1, Hamartin gRNA vector 1 in pCas-Guide CRISPR vector

KN213332G2, Hamartin gRNA vector 2 in pCas-Guide CRISPR vector

KN213332RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000368, NM_001008567, NM_001162426, NM_001162427, N63914, NM_001362177
UniProt ID Q92574
Synonyms LAM; TSC
Summary This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signalling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including Tsc2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis. provided by RefSeq, Apr 2018
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Resources
Other Versions
SKU Description Size Price
GA104986 TSC1 CRISPRa kit - CRISPR gene activation of human TSC complex subunit 1 1 kit
$1,657.00
KN213332 TSC1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213332BN TSC1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213332LP TSC1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN413332 TSC1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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