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Dopamine beta Hydroxylase (DBH) Human Gene Knockout Kit (CRISPR)

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SKU
KN212355LP
DBH - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "Dopamine beta Hydroxylase or NM_000787"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol Dopamine beta Hydroxylase
Locus ID 1621
Components

KN212355G1, Dopamine beta Hydroxylase gRNA vector 1 in pCas-Guide CRISPR vector

KN212355G2, Dopamine beta Hydroxylase gRNA vector 2 in pCas-Guide CRISPR vector

KN212355LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000787
UniProt ID P09172
Synonyms DBM
Summary The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. provided by RefSeq, Aug 2017
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Other Versions
SKU Description Size Price
GA101143 DBH CRISPRa kit - CRISPR gene activation of human dopamine beta-hydroxylase 1 kit
$1,657.00
KN212355 DBH - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN212355BN DBH - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN212355RB DBH - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN412355 DBH - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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