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p16INK4A (CDKN2A) Human Gene Knockout Kit (CRISPR)

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SKU
KN211784LP
CDKN2A - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol p16INK4A
Locus ID 1029
Components

KN211784G1, p16INK4A gRNA vector 1 in pCas-Guide CRISPR vector

KN211784G2, p16INK4A gRNA vector 2 in pCas-Guide CRISPR vector

KN211784LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000077, NM_001195132, NM_058195, NM_058196, NM_058197, NM_001363763
UniProt ID P42771
Synonyms ARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4
Summary This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. provided by RefSeq, Sep 2012
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Documents
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Other Versions
SKU Description Size Price
GA100741 CDKN2A CRISPRa kit - CRISPR gene activation of human cyclin dependent kinase inhibitor 2A 1 kit
$1,657.00
KN211784 CDKN2A - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN211784BN CDKN2A - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN211784RB CDKN2A - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN411784 CDKN2A - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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