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PTCH1 Human Gene Knockout Kit (CRISPR)

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SKU
KN211551BN
PTCH1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "PTCH1 or NM_000264"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol PTCH1
Locus ID 5727
Components

KN211551G1, PTCH1 gRNA vector 1 in pCas-Guide CRISPR vector

KN211551G2, PTCH1 gRNA vector 2 in pCas-Guide CRISPR vector

KN211551BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000264, NM_001083602, NM_001083603, NM_001083604, NM_001083605, NM_001083606, NM_001083607, NM_001354918, NM_001354919, NR_149061
UniProt ID Q13635
Synonyms BCNS; HPE7; NBCCS; PTC; PTC1; PTCH; PTCH11
Summary This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. provided by RefSeq, Aug 2017
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Documents
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Other Versions
SKU Description Size Price
GA103893 PTCH1 CRISPRa kit - CRISPR gene activation of human patched 1 1 kit
$1,657.00
KN211551 PTCH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN211551LP PTCH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN211551RB PTCH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN411551 PTCH1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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