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PAPP A (PAPPA) Human Gene Knockout Kit (CRISPR)

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SKU
KN209767RB
PAPPA - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (4)

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Other products for "PAPP A or NM_002581"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol PAPP A
Locus ID 5069
Components

KN209767G1, PAPP A gRNA vector 1 in pCas-Guide CRISPR vector

KN209767G2, PAPP A gRNA vector 2 in pCas-Guide CRISPR vector

KN209767RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_002581
UniProt ID Q13219
Synonyms ASBABP2; DIPLA1; IGFBP-4ase; PAPA; PAPP-A; PAPPA1
Summary This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. provided by RefSeq, Aug 2017
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Documents
Resources
Other Versions
SKU Description Size Price
GA103385 PAPPA CRISPRa kit - CRISPR gene activation of human pappalysin 1 1 kit
$1,657.00
KN209767 PAPPA - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN209767BN PAPPA - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN209767LP PAPPA - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN409767 PAPPA - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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