NUMB Human Gene Knockout Kit (CRISPR)

SKU KN209744LP

NUMB - human gene knockout kit via CRISPR, HDR mediated

Product Data

• Format: 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
• Vector: Luciferase-Puro
• Target Symbol: NUMB
• Locus ID: 8650
• Components:

  KN209744G1, NUMB gRNA vector 1 in pCas-Guide CRISPR vector

  KN209744G2, NUMB gRNA vector 2 in pCas-Guide CRISPR vector

  KN209744LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001005743, NM_001005744, NM_001005745, NM_001320114, NM_003744
• UniProt ID: P49757
• Synonyms: C14orf41; c14_5527; S171
• Summary: The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
• Shipping: Ambient