OriGene Logo

Customer Login

Checkout as a new customer

Creating an account has many benefits:

  • See order and shipping status
  • Track order history
  • Check out faster
Create an Account

Niemann Pick C1 (NPC1) Human Gene Knockout Kit (CRISPR)

Be the first to review this product
SKU
KN209258RB
NPC1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (4)

TA336646 Rabbit Polyclonal Niemann-Pick C1 Antibody
100 ul
$585.00
SC120010 NPC1 (untagged)-Human Niemann-Pick disease, type C1 (NPC1)
10 ug
$1,670.00
GE100003 pCAS-Scramble, pCas-Guide vector with a scrambled sequence as a negative control (10 µg)
10 ug
$470.00
TT300007S A non-viral, non-electroporation, non-liposomal transfection kit using engineered mammalian proteins, tailored for high-efficiency delivery into a wide range of primary cells and difficult to transfect cell lines such as immune cells, stem cells, and neuronal cells.
20 ul
$265.00

Other products for "Niemann Pick C1 or NM_000271"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol Niemann Pick C1
Locus ID 4864
Components

KN209258G1, Niemann Pick C1 gRNA vector 1 in pCas-Guide CRISPR vector

KN209258G2, Niemann Pick C1 gRNA vector 2 in pCas-Guide CRISPR vector

KN209258RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000271
UniProt ID O15118
Synonyms NPC
Summary This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.provided by RefSeq, Aug 2009
Shipping Ambient
Reviews
Write Review
 
 
 
 
 

Be the first to review this product

Please note:
Only reviews with images are eligible for a $20/20€ Amazon gift card.
Reviews without images are eligible for a $10/10€ Amazon gift card.
For more details about the terms and conditions, please visit the promotion page.

Review image
Documents
Resources
Other Versions
SKU Description Size Price
GA103250 NPC1 CRISPRa kit - CRISPR gene activation of human NPC intracellular cholesterol transporter 1 1 kit
$1,657.00
KN209258 NPC1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN209258BN NPC1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN209258LP NPC1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN409258 NPC1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

file-alt Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Related Products