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gamma Adducin (ADD3) Human Gene Knockout Kit (CRISPR)

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SKU
KN209129LP
ADD3 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "gamma Adducin or NM_001121"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol gamma Adducin
Locus ID 120
Components

KN209129G1, gamma Adducin gRNA vector 1 in pCas-Guide CRISPR vector

KN209129G2, gamma Adducin gRNA vector 2 in pCas-Guide CRISPR vector

KN209129LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001121, NM_016824, NM_019903, NM_001320591, NM_001320592, NM_001320593, NM_001320594
UniProt ID Q9UEY8
Synonyms ADDL
Summary Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. provided by RefSeq, Jul 2008
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Documents
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Other Versions
SKU Description Size Price
GA100082 ADD3 CRISPRa kit - CRISPR gene activation of human adducin 3 1 kit
$1,657.00
KN209129 ADD3 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN209129BN ADD3 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN209129RB ADD3 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN409129 ADD3 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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