KDM1A Human Gene Knockout Kit (CRISPR)

CAT#: KN208480BN

KDM1A - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
• Donor DNA: mBFP-Neo
• Symbol: KDM1A
• Locus ID: 23028
• Components:

  KN208480G1, KDM1A gRNA vector 1 in pCas-Guide CRISPR vector

  KN208480G2, KDM1A gRNA vector 2 in pCas-Guide CRISPR vector

  KN208480BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001009999, NM_015013, NM_001363654
• UniProt ID: O60341
• Synonyms: AOF2; BHC110; CPRF; KDM1; LSD1
• Summary: This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]