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NFKB1 Human Gene Knockout Kit (CRISPR)

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SKU
KN208384LP
NFKB1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "NFKB1 or NM_001165412"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol NFKB1
Locus ID 4790
Components

KN208384G1, NFKB1 gRNA vector 1 in pCas-Guide CRISPR vector

KN208384G2, NFKB1 gRNA vector 2 in pCas-Guide CRISPR vector

KN208384LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001165412, NM_001319226, NM_003998
UniProt ID P19838
Synonyms CVID12; EBP-1; KBF1; NF-kappa-B; NF-kappaB; NF-kB1; NFkappaB; NFKB-p50; NFKB-p105; p50; p105
Summary This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. provided by RefSeq, Aug 2020
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Documents
Resources
Other Versions
SKU Description Size Price
GA103192 NFKB1 CRISPRa kit - CRISPR gene activation of human nuclear factor kappa B subunit 1 1 kit
$1,657.00
KN208384 NFKB1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN208384BN NFKB1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN208384RB NFKB1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN408384 NFKB1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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