ADA2 Human Gene Knockout Kit (CRISPR)

SKU KN208252BN

CECR1 - human gene knockout kit via CRISPR, HDR mediated

Product Data

• Format: 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
• Vector: mBFP-Neo
• Target Symbol: ADA2
• Locus ID: 51816
• Components:

  KN208252G1, ADA2 gRNA vector 1 in pCas-Guide CRISPR vector

  KN208252G2, ADA2 gRNA vector 2 in pCas-Guide CRISPR vector

  KN208252BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001282225, NM_001282226, NM_001282227, NM_001282228, NM_001282229, NM_017424, NM_177405
• UniProt ID: Q9NZK5
• Synonyms: ADA2; ADGF; IDGFL; PAN; SNEDS
• Summary: This gene encodes a member of a subfamily of the adenosine deaminase protein family. The encoded protein is one of two adenosine deaminases found in humans, which regulate levels of the signaling molecule, adenosine. The encoded protein is secreted from monocytes undergoing differentiation and may regulate cell proliferation and differentiation. This gene may be responsible for some of the phenotypic features associated with cat eye syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
• Shipping: Ambient