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JNK2 (MAPK9) Human Gene Knockout Kit (CRISPR)

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SKU
KN207608LP
MAPK9 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol JNK2
Locus ID 5601
Components

KN207608G1, JNK2 gRNA vector 1 in pCas-Guide CRISPR vector

KN207608G2, JNK2 gRNA vector 2 in pCas-Guide CRISPR vector

KN207608LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001135044, NM_001308244, NM_002752, NM_139068, NM_139069, NM_139070, NM_001364610, NM_001364607, NM_001364608, NM_001364609, NM_001364612, NM_001364613, NM_001364611
UniProt ID P45984
Synonyms JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a
Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. provided by RefSeq, Sep 2008
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Other Versions
SKU Description Size Price
GA103791 MAPK9 CRISPRa kit - CRISPR gene activation of human mitogen-activated protein kinase 9 1 kit
$1,657.00
KN207608 MAPK9 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN207608BN MAPK9 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN207608RB MAPK9 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN407608 MAPK9 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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