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Angiotensin Converting Enzyme 1 (ACE) Human Gene Knockout Kit (CRISPR)

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SKU
KN205392LP
ACE - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "Angiotensin Converting Enzyme 1 or NM_000789"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol Angiotensin Converting Enzyme 1
Locus ID 1636
Components

KN205392G1, Angiotensin Converting Enzyme 1 gRNA vector 1 in pCas-Guide CRISPR vector

KN205392G2, Angiotensin Converting Enzyme 1 gRNA vector 2 in pCas-Guide CRISPR vector

KN205392LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000789, NM_001178057, NM_152830, NM_152831
UniProt ID P12821
Synonyms ACE1; CD143; DCP; DCP1
Summary This gene encodes an enzyme involved in blood pressure regulation and electrolyte balance. It catalyzes the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This angiotensin converting enzyme (ACE) also inactivates the vasodilator protein, bradykinin. Accordingly, the encoded enzyme increases blood pressure and is a drug target of ACE inhibitors, which are often prescribed to reduce blood pressure. This enzyme additionally plays a role in fertility through its ability to cleave and release GPI-anchored membrane proteins in spermatozoa. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme. This polymorphism, as well as mutations in this gene, have been implicated in a wide variety of diseases including cardiovascular pathophysiologies, psoriasis, renal disease, stroke, and Alzheimer's disease. Regulation of the homologous ACE2 gene may be involved in progression of disease caused by several human coronaviruses, including SARS-CoV and SARS-CoV-2. Alternative splicing results in multiple transcript variants encoding both somatic (sACE) and male-specific testicular (tACE) isoforms. provided by RefSeq, Sep 2020
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Other Versions
SKU Description Size Price
GA101153 ACE CRISPRa kit - CRISPR gene activation of human angiotensin I converting enzyme 1 kit
$1,657.00
KN205392 ACE - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN205392BN ACE - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN205392RB ACE - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN405392 ACE - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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