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Glucocorticoid Receptor (NR3C1) Human Gene Knockout Kit (CRISPR)

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SKU
KN204878LP
NR3C1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "Glucocorticoid Receptor or NM_000176"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol Glucocorticoid Receptor
Locus ID 2908
Components

KN204878G1, Glucocorticoid Receptor gRNA vector 1 in pCas-Guide CRISPR vector

KN204878G2, Glucocorticoid Receptor gRNA vector 2 in pCas-Guide CRISPR vector

KN204878LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000176, NM_001018074, NM_001018075, NM_001018076, NM_001018077, NM_001020825, NM_001024094, NM_001204258, NM_001204259, NM_001204260, NM_001204261, NM_001204262, NM_001204263, NM_001204264, NM_001204265, NM_001364182, NM_001364184, NR_157096, NM_001364180, NM_001364181, NM_001364183, NM_001364185
UniProt ID P04150
Synonyms GCCR; GCR; GCRST; GR; GRL
Summary This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). provided by RefSeq, Feb 2011
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Documents
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Other Versions
SKU Description Size Price
GA101964 NR3C1 CRISPRa kit - CRISPR gene activation of human nuclear receptor subfamily 3 group C member 1 1 kit
$1,657.00
KN204878 NR3C1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN204878BN NR3C1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN204878RB NR3C1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN404878 NR3C1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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