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Human Glucocorticoid Receptor (NR3C1) activation kit by CRISPRa

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SKU
GA101964
NR3C1 CRISPRa kit - CRISPR gene activation of human nuclear receptor subfamily 3 group C member 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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Other products for "NR3C1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol NR3C1
Locus ID 2908
Components

GA101964G1, Glucocorticoid Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA101964G2, Glucocorticoid Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA101964G3, Glucocorticoid Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_000176, NM_001018074, NM_001018075, NM_001018076, NM_001018077, NM_001020825, NM_001024094, NM_001204258, NM_001204259, NM_001204260, NM_001204261, NM_001204262, NM_001204263, NM_001204264, NM_001204265, NM_001364182, NM_001364184, NR_157096, NM_001364180, NM_001364181, NM_001364183, NM_001364185
UniProt ID P04150
Synonyms GCCR; GCR; GCRST; GR; GRL
Summary This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). provided by RefSeq, Feb 2011
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Documents
Resources
Other Versions
SKU Description Size Price
KN204878 NR3C1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN204878BN NR3C1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN204878LP NR3C1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN204878RB NR3C1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN404878 NR3C1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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