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PYK2 (PTK2B) Human Gene Knockout Kit (CRISPR)

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SKU
KN203808BN
PTK2B - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "PYK2 or NM_004103"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol PYK2
Locus ID 2185
Components

KN203808G1, PYK2 gRNA vector 1 in pCas-Guide CRISPR vector

KN203808G2, PYK2 gRNA vector 2 in pCas-Guide CRISPR vector

KN203808BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_004103, NM_173174, NM_173175, NM_173176
UniProt ID Q14289
Synonyms CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2; RAFTK
Summary This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
GA101525 PTK2B CRISPRa kit - CRISPR gene activation of human protein tyrosine kinase 2 beta 1 kit
$1,657.00
KN203808 PTK2B - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN203808LP PTK2B - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN203808RB PTK2B - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN403808 PTK2B - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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