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CCN1 (CYR61) Human Gene Knockout Kit (CRISPR)

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SKU
KN203492
CYR61 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "CCN1 or NM_001554"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control
Vector GFP-puro
Target Symbol CCN1
Locus ID 3491
Components

KN203492G1, CCN1 gRNA vector 1 in pCas-Guide CRISPR vector, Target Sequence: GACGACTAAGGCGAGCGCCC

KN203492G2, CCN1 gRNA vector 2 in pCas-Guide CRISPR vector, Target Sequence: AACTCACCAGCCTGGTCAAG

KN203492D, donor DNA containing left and right homologous arms and GFP-puro functional cassette.

Homologous arm and GFP-puro sequences:

pUC vector backbone in gray; Left arm sequence in blue; GFP-puro in green; Right arm in violet

CACGCCCCAA AGAACCCTTC CCAACATAAG TCGTAATTTA AGGTGGAAAA AACGAACTGT TTTCTTGACG GGTCTGGGAC ACACACACAC ACACACACAC ACACACACAC ACCCCCCGAA CTGTTTTCTT GACGGGTCTG GGAGACAGAC ACACACACAG ACACACACAC ACACACACAC ACACACACAC ACACACACAC ACACACACAC ACACAAAGGT GCAATGGAGC CAGGGGAGGC GCTTGGCAGC AGCCCGCGCC AACCAGCATT CCTGAGATGT TTGAGAATTC TGGAACGCGC AGACAGAGCC GACGTCACTG CAACACGCGG CGCCTCCGCC GGCCCGTATA AAAGGCGGGC TCCGGGGCGC CTGGGCAGAC CGCGAGCGAG AGCGCCCCCG AGCAGCGCCC GCGCCCTCCG CGCCTTCTCC GCCGGGACCT CGAGCGAAAG ACGCCCGCCC GCCGCCCAGC CCTCGCCTCC CTGCCCACCG GGCCCACCGC GCCGCCACCC CGACCCCGCT GCGCACGGCC TGTCCGCTGC ACACCAGCTT GTTGGCGTCT TCGTCGCCGC GCTCGCCCCG GGCTACTCCT GCGCGCCACA CCCCTTCCCC TGGTCCCAGA TTGCCCACGG CAGGAAAAGT TAAAAAGTTC GCGATCGTTT GCGGGTAGCC GTTTCTTTAA GCACTCTCCC CCTCCCCCCG AAGACGTGTC GGGACCTCTT GGTGGGAGCA GCCTTCCGAG GTGGCCGGGC TGGACGAGAT CAGAGGCTCC CCGTCGATAG GGTCGGAGAC CCCCGTCCCT CACTGCGGCA GCCGCGGCGC CCCTCCTGCG CACCGCGCCG AGTCTCACGC GTATCTTCTC CCCCTTCCAG GCGCTCTCCA CCTGCCCCGC TGCCTGCCAC TGCCCCCTGG AGGCGCCCAA GTGCGCGCCG GGAGTCGGGC TGGTCCGGGA CGGCTGCGGC TGCTGTAAGG TCTGCGCCAA GCAGCTCAAC GAGGACTGCA GCAAAACGCA GCCCTGCGAC CACACCAAGG GGCTGGAATG CAACTTCGGC GCCAGCTCCA CCGCTCTGAA GGGGATCTGC AGAGGTAAGA TGCTTGTGGT TTGGCCCCTT TAAAAAAAAT ACTAGTCCCC ATAGTCCAGA AGTTTAGTAA TTCTGAGACC ATGTATGGTG ATGCTTTGTT GTTGGTAGCT TGGCAGAAAG

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001554
UniProt ID O00622
Synonyms CCN1; GIG1; IGFBP10
Summary The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. provided by RefSeq, Sep 2011
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Documents
Resources
Other Versions
SKU Description Size Price
GA102360 CCN1 CRISPRa kit - CRISPR gene activation of human cellular communication network factor 1 1 kit
$1,657.00
KN203492BN CYR61 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN203492LP CYR61 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN203492RB CYR61 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN403492 CYR61 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

file-alt Citations

Cyr61/CCN1 regulates dCK and CTGF and Causes Gemcitabine Resistant Phenotype in Pancreatic Ductal Adenocarcinoma
Maity, Ghosh, Gupta et al
Mol. Cancer Ther. (2019)
AI Summary: OriGene's CYR61/CCN1 Human Gene Knockout Kit (CRISPR) was used to generate CYR61 gene knockout AsPC-1 pancreatic cancer cells, enabling the study of CYR61/CCN1's role in gemcitabine resistance in this research.
Snippet: Human CYR61 gene knock- out AsPC-1 cells were generated using CYR61/CCN1 Human Gene Knockout Kit (CRISPR) (OriGene, Rockville, MD). Three separate transfections were carried out in AsPC-1 cells. Donor DNA was co
Showing 1-1 of 1 papers.
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