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MHF2 (CENPX) Human Gene Knockout Kit (CRISPR)

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SKU
KN203240RB
STRA13 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "MHF2 or NM_001271006"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol MHF2
Locus ID 201254
Components

KN203240G1, MHF2 gRNA vector 1 in pCas-Guide CRISPR vector

KN203240G2, MHF2 gRNA vector 2 in pCas-Guide CRISPR vector

KN203240RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001271006, NM_001271007, NM_001330536, NM_144998
UniProt ID A8MT69
Synonyms CENP-X; D9; FAAP10; MHF2; STRA13
Summary DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428, PubMed:20347429). DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (PubMed:20347429).UniProtKB/Swiss-Prot Function
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Other Versions
SKU Description Size Price
GA116386 CENPX CRISPRa kit - CRISPR gene activation of human centromere protein X 1 kit
$1,657.00
KN203240 CENPX - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN203240BN STRA13 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN203240LP STRA13 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN403240 CENPX - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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