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Tissue Factor (F3) Human Gene Knockout Kit (CRISPR)

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SKU
KN203142RB
F3 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "Tissue Factor or NM_001178096"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol Tissue Factor
Locus ID 2152
Components

KN203142G1, Tissue Factor gRNA vector 1 in pCas-Guide CRISPR vector

KN203142G2, Tissue Factor gRNA vector 2 in pCas-Guide CRISPR vector

KN203142RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001178096, NM_001993
UniProt ID P13726
Synonyms CD142; TF; TFA
Summary This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.provided by RefSeq, Aug 2020
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Documents
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Other Versions
SKU Description Size Price
GA101499 F3 CRISPRa kit - CRISPR gene activation of human coagulation factor III, tissue factor 1 kit
$1,657.00
KN203142 F3 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN203142BN F3 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN203142LP F3 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN403142 F3 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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