MYD88 Human Gene Knockout Kit (CRISPR)
CAT#: KN202253RB
MYD88 - human gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro Luciferase-Puro mBFP-Neo
HDR-mediated knockout kit validation
USD 1,657.00
2 Weeks*
USD 450.00
USD 450.00
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control |
Donor DNA | RFP-BSD |
Symbol | MYD88 |
Locus ID | 4615 |
Components |
KN202253G1, MYD88 gRNA vector 1 in pCas-Guide CRISPR vector KN202253G2, MYD88 gRNA vector 2 in pCas-Guide CRISPR vector KN202253RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001172566, NM_001172567, NM_001172568, NM_001172569, NM_002468, NM_001365877, NM_001365876 |
UniProt ID | Q99836 |
Synonyms | MYD88D |
Summary | This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] |
Documents
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FAQs |
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Resources
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