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alpha 1 Antitrypsin (SERPINA1) Human Gene Knockout Kit (CRISPR)

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SKU
KN202082
SERPINA1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control
Vector GFP-puro
Target Symbol alpha 1 Antitrypsin
Locus ID 5265
Components

KN202082G1, alpha 1 Antitrypsin gRNA vector 1 in pCas-Guide CRISPR vector, Target Sequence: ATGCCGTCTTCTGTCTCGTG

KN202082G2, alpha 1 Antitrypsin gRNA vector 2 in pCas-Guide CRISPR vector, Target Sequence: TCCCTGGCTGAGGATCCCCA

KN202082D, donor DNA containing left and right homologous arms and GFP-puro functional cassette.

Homologous arm and GFP-puro sequences:

pUC vector backbone in gray; Left arm sequence in blue; GFP-puro in green; Right arm in violet

CTTCTGTGCA GCAGTTTCCC TGGCCACTAA ATAGTGGGAT TAGATAGAAG CCCTCCAAGG GCTTCCAGCT TGACATGATT CTTGATTCTG ATCTGGCCCG ATTCCTGGAT AATCGTGGGC AGGCCCATTC CTCTTCTTGT GCCTCATTTT CTTCTTTTGT AAAACAATGG CTGTACCATT TGCATCTTAG GGTCATTGCA GATGTAAGTG TTGCTGTCCA GAGCCTGGGT GCAGGACCTA GATGTAGGAT TCTGGTTCTG CTACTTCCTC AGTGACATTG AATAGCTGAC CTAATCTCTC TGGCTTTGGT TTCTTCATCT GTAAAAGAAG GATATTAGCA TTAGCACCTC ACGGGATTGT TACAAGAAAG CAATGAATTA ACACATGTGA GCACGGAGAA CAGTGCTTGG CATATGGTAA GCACTACGTA CATTTTGCTA TTCTTCTGAT TCTTTCAGTG TTACTGATGT CGGCAAGTAC TTGGCACAGG CTGGTTTAAT AATCCCTAGG CACTTCCACG TGGTGTCAAT CCCTGATCAC TGGGAGTCAT CATGTGCCTT GACTCGGGGC CTGGCCCCCC CATCTCTGTC TTGCAGGACA GAAGACAGAT ACATCCCACC ATGATCAGGA TCACCCAACC TTCAACAAGA TCACCCCCAA CCTGGCTGAG TTCGCCTTCA GCCTATACCG CCAGCTGGCA CACCAGTCCA ACAGCACCAA TATCTTCTTC TCCCCAGTGA GCATCGCTAC AGCCTTTGCA ATGCTCTCCC TGGGGACCAA GGCTGACACT CACGATGAAA TCCTGGAGGG CCTGAATTTC AACCTCACGG AGATTCCGGA GGCTCAGATC CATGAAGGCT TCCAGGAACT CCTCCGTACC CTCAACCAGC CAGACAGCCA GCTCCAGCTG ACCACCGGCA ATGGCCTGTT CCTCAGCGAG GGCCTGAAGC TAGTGGATAA GTTTTTGGAG GATGTTAAAA AGTTGTACCA CTCAGAAGCC TTCACTGTCA ACTTCGGGGA CACCGAAGAG GCCAAGAAAC AGATCAACGA TTACGTGGAG AAGGGTACTC AAGGGAAAAT TGTGGATTTG GTCAAGGAGC TTGACAGAGA CACAGTTTTT GCTCTGGTGA ATTACATCTT CTTTAAAGGT AAGGTTGCTC AACCAGCCTG AGCTGTTCCC ATAGAAACAA GCAAAAATAT

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000295, NM_001002235, NM_001002236, NM_001127700, NM_001127701, NM_001127702, NM_001127703, NM_001127704, NM_001127705, NM_001127706, NM_001127707
UniProt ID P01009
Synonyms A1A; A1AT; AAT; alpha1AT; PI; PI1; PRO2275
Summary The protein encoded by this gene is a serine protease inhibitor belonging to the serpin superfamily whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. This protein is produced in the liver, the bone marrow, by lymphocytic and monocytic cells in lymphoid tissue, and by the Paneth cells of the gut. Defects in this gene are associated with chronic obstructive pulmonary disease, emphysema, and chronic liver disease. Several transcript variants encoding the same protein have been found for this gene. provided by RefSeq, Aug 2020
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Documents
Resources
Other Versions
SKU Description Size Price
GA103534 SERPINA1 CRISPRa kit - CRISPR gene activation of human serpin family A member 1 1 kit
$1,657.00
KN202082BN SERPINA1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202082LP SERPINA1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN202082RB SERPINA1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN402082 SERPINA1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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