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Aconitase 1 (ACO1) Human Gene Knockout Kit (CRISPR)

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SKU
KN201857LP
ACO1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (4)

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Other products for "Aconitase 1 or NM_001278352"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol Aconitase 1
Locus ID 48
Components

KN201857G1, Aconitase 1 gRNA vector 1 in pCas-Guide CRISPR vector

KN201857G2, Aconitase 1 gRNA vector 2 in pCas-Guide CRISPR vector

KN201857LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001278352, NM_002197, NM_001362840
UniProt ID P21399
Synonyms ACONS; HEL60; IREB1; IREBP; IREBP1; IRP1
Summary The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants provided by RefSeq, Jan 2014
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Documents
Resources
Other Versions
SKU Description Size Price
GA100036 ACO1 CRISPRa kit - CRISPR gene activation of human aconitase 1 1 kit
$1,657.00
KN201857 ACO1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201857BN ACO1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201857RB ACO1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN401857 ACO1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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