EXT1 Human Gene Knockout Kit (CRISPR)

CAT#: KN200644BN

EXT1 - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
• Donor DNA: mBFP-Neo
• Symbol: EXT1
• Locus ID: 2131
• Components:

  KN200644G1, EXT1 gRNA vector 1 in pCas-Guide CRISPR vector

  KN200644G2, EXT1 gRNA vector 2 in pCas-Guide CRISPR vector

  KN200644BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_000127
• UniProt ID: Q16394
• Synonyms: EXT; LGCR; LGS; TRPS2; TTV
• Summary: This gene encodes an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type I form of multiple exostoses. [provided by RefSeq, Jul 2008]