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AKR1C3 Human Gene Knockout Kit (CRISPR)

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SKU
KN200210LP
AKR1C3 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "AKR1C3 or NM_001253908"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol AKR1C3
Locus ID 8644
Components

KN200210G1, AKR1C3 gRNA vector 1 in pCas-Guide CRISPR vector

KN200210G2, AKR1C3 gRNA vector 2 in pCas-Guide CRISPR vector

KN200210LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001253908, NM_001253909, NM_003739
UniProt ID P42330
Synonyms DD3; DDX; HA1753; HAKRB; HAKRe; hluPGFS; HSD17B5; PGFS
Summary This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Dec 2011
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Other Versions
SKU Description Size Price
GA105727 AKR1C3 CRISPRa kit - CRISPR gene activation of human aldo-keto reductase family 1 member C3 1 kit
$1,657.00
KN200210 AKR1C3 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN200210BN AKR1C3 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN200210RB AKR1C3 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN400210 AKR1C3 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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