Mouse Drc1 activation kit by CRISPRa

SKU GA217162

Drc1 CRISPRa kit - CRISPR gene activation of mouse dynein regulatory complex subunit 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Drc1
• Locus ID: 381738
• Components:

  GA217162G1, Drc1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA217162G2, Drc1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA217162G3, Drc1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001033460
• UniProt ID: Q3USS3
• Synonyms: b2b1654Clo; Ccdc164; Gm1060
• Summary: Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.[UniProtKB/Swiss-Prot Function]