Mouse Jph4 activation kit by CRISPRa

SKU GA216397

Jph4 CRISPRa kit - CRISPR gene activation of mouse junctophilin 4

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Jph4
• Locus ID: 319984
• Components:

  GA216397G1, Jph4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA216397G2, Jph4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA216397G3, Jph4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001003829, NM_177049
• UniProt ID: Q80WT0
• Synonyms: 9330157P13Rik; AI425998; JP-4; JPHL1
• Summary: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory.[UniProtKB/Swiss-Prot Function]