Mouse Ltbp1 activation kit by CRISPRa

SKU GA215972

Ltbp1 CRISPRa kit - CRISPR gene activation of mouse latent transforming growth factor beta binding protein 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Ltbp1
• Locus ID: 268977
• Components:

  GA215972G1, Ltbp1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA215972G2, Ltbp1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA215972G3, Ltbp1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001331233, NM_001331234, NM_001331235, NM_001331236, NM_001331237, NM_019919, NM_206958
• UniProt ID: Q8CG19
• Synonyms: 9430031G15Rik; 9830146M04; b2b1000Clo; Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb
• Summary: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta.[UniProtKB/Swiss-Prot Function]