Mouse Slc38a9 activation kit by CRISPRa

SKU GA215943

Slc38a9 CRISPRa kit - CRISPR gene activation of mouse solute carrier family 38, member 9

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Slc38a9
• Locus ID: 268706
• Components:

  GA215943G1, Slc38a9 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA215943G2, Slc38a9 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA215943G3, Slc38a9 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_178746, NM_175376
• UniProt ID: Q8BGD6
• Synonyms: 4833412L08Rik; 6720411P22Rik; 9130023D20Rik; 9430067K09Rik; A730092C09
• Summary: Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids. Acts as an arginine sensor. Following activation by arginine binding, mediates transport of leucine, tyrosine and phenylalanine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation.[UniProtKB/Swiss-Prot Function]