Mouse Malt1 activation kit by CRISPRa

SKU GA214919

Malt1 CRISPRa kit - CRISPR gene activation of mouse MALT1 paracaspase

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Malt1
• Locus ID: 240354
• Components:

  GA214919G1, Malt1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA214919G2, Malt1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA214919G3, Malt1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_172833, NM_001365019
• UniProt ID: Q2TBA3
• Synonyms: A630046N12; D430033E09Rik; Pcasp1
• Summary: Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity (By similarity). MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (PubMed:25282160).[UniProtKB/Swiss-Prot Function]