Mouse Rab8b activation kit by CRISPRa

SKU GA214627

Rab8b CRISPRa kit - CRISPR gene activation of mouse RAB8B, member RAS oncogene family

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Rab8b
• Locus ID: 235442
• Components:

  GA214627G1, Rab8b gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA214627G2, Rab8b gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA214627G3, Rab8b gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_173413
• UniProt ID: P61028
• Synonyms: 5930437D16; D330025I23Rik
• Summary: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity).[UniProtKB/Swiss-Prot Function]