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Mouse Gcn1 activation kit by CRISPRa

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SKU
GA214280
Gcn1 CRISPRa kit - CRISPR gene activation of mouse GCN1 activator of EIF2AK4
  $1,657.00
4 Weeks*

Other products for "Gcn1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Gcn1
Locus ID 231659
Components

GA214280G1, Gcn1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA214280G2, Gcn1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA214280G3, Gcn1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_172719
UniProt ID E9PVA8
Synonyms 4932409G22; AL022764; G431004K08Rik; Gcn1; GCN1L; mKIAA0219
Summary Acts as a positive activator of the GCN2 protein kinase activity in response to amino acid starvation (PubMed:15937339). Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity (By similarity). Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:24333428).UniProtKB/Swiss-Prot Function
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Documents
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Other Versions
SKU Description Size Price
KN506370 Gcn1l1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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