Mouse Man1b1 activation kit by CRISPRa

SKU GA213941

Man1b1 CRISPRa kit - CRISPR gene activation of mouse mannosidase, alpha, class 1B, member 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Man1b1
• Locus ID: 227619
• Components:

  GA213941G1, Man1b1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA213941G2, Man1b1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA213941G3, Man1b1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001029983
• UniProt ID: A2AJ15
• Synonyms: E430019H13Rik; ERMan1; Gm108; MANA-ER
• Summary: Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2) (By similarity).[UniProtKB/Swiss-Prot Function]