Mouse Erfe activation kit by CRISPRa

SKU GA213924

Erfe CRISPRa kit - CRISPR gene activation of mouse erythroferrone

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Erfe
• Locus ID: 227358
• Components:

  GA213924G1, Erfe gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA213924G2, Erfe gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA213924G3, Erfe gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_173395
• UniProt ID: Q6PGN1
• Synonyms: 4832406C22; Fam132b; myonectin
• Summary: Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores (PubMed:24880340). Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (PubMed:22351773).[UniProtKB/Swiss-Prot Function]