Mouse Ppp2r5b activation kit by CRISPRa

SKU GA213795

Ppp2r5b CRISPRa kit - CRISPR gene activation of mouse protein phosphatase 2, regulatory subunit B', beta

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Ppp2r5b
• Locus ID: 225849
• Components:

  GA213795G1, Ppp2r5b gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA213795G2, Ppp2r5b gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA213795G3, Ppp2r5b gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_198168
• UniProt ID: Q6PD28
• Synonyms: B'beta; BC026670
• Summary: As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.[UniProtKB/Swiss-Prot Function]