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Mouse Rapgef3 activation kit by CRISPRa

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SKU
GA213650
Rapgef3 CRISPRa kit - CRISPR gene activation of mouse Rap guanine nucleotide exchange factor (GEF) 3
  $1,657.00
4 Weeks*

Other products for "Rapgef3"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Rapgef3
Locus ID 223864
Components

GA213650G1, Rapgef3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA213650G2, Rapgef3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA213650G3, Rapgef3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001177810, NM_001177811, NM_144850, NM_001357630
UniProt ID Q8VCC8
Synonyms 2310016P22Rik; 9330170P05Rik; Epac; Epac1
Summary Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN514474 Rapgef3 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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