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Mouse Hmbox1 activation kit by CRISPRa

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SKU
GA213599
Hmbox1 CRISPRa kit - CRISPR gene activation of mouse homeobox containing 1
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

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Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Hmbox1
Locus ID 219150
Components

GA213599G1, Hmbox1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA213599G2, Hmbox1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA213599G3, Hmbox1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001347626, NM_001347627, NM_177338
UniProt ID Q8BJA3
Synonyms AI451877; AI604847; F830020C16Rik
Summary Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (By similarity). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (By similarity). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (PubMed:23685356). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (By similarity). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (By similarity). Might also be involved in the DNA damage response at telomeres (By similarity).UniProtKB/Swiss-Prot Function
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Documents
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Other Versions
SKU Description Size Price
KN507809 Hmbox1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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