Mouse Nudt18 activation kit by CRISPRa

SKU GA213157

Nudt18 CRISPRa kit - CRISPR gene activation of mouse nudix (nucleoside diphosphate linked moiety X)-type motif 18

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Nudt18
• Locus ID: 213484
• Components:

  GA213157G1, Nudt18 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA213157G2, Nudt18 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA213157G3, Nudt18 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_153136, NM_001360474, NM_001360475
• UniProt ID: Q3U2V3
• Synonyms: BC036718
• Summary: Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools (By similarity).[UniProtKB/Swiss-Prot Function]