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Mouse Esrp1 activation kit by CRISPRa

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SKU
GA212833
Esrp1 CRISPRa kit - CRISPR gene activation of mouse epithelial splicing regulatory protein 1
  $1,657.00
4 Weeks*

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Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Esrp1
Locus ID 207920
Components

GA212833G1, Esrp1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA212833G2, Esrp1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA212833G3, Esrp1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001290383, NM_001347052, NM_194055
UniProt ID Q3US41
Synonyms 2210008M09Rik; A630065D16; BC031468; Rbm35a
Summary mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (PubMed:29107558).UniProtKB/Swiss-Prot Function
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Documents
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Other Versions
SKU Description Size Price
KN505382 Esrp1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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