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Mouse Ppargc1b activation kit by CRISPRa

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SKU
GA212621
Ppargc1b CRISPRa kit - CRISPR gene activation of mouse peroxisome proliferative activated receptor, gamma, coactivator 1 beta
  $1,657.00
4 Weeks*

Other products for "Ppargc1b"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Ppargc1b
Locus ID 170826
Components

GA212621G1, Ppargc1b gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA212621G2, Ppargc1b gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA212621G3, Ppargc1b gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_133249, NM_001364996
UniProt ID Q8VHJ7
Synonyms 4631412G21Rik; Perc
Summary Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta-oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Induces also the expression of mitochondrial genes involved in oxidative metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.UniProtKB/Swiss-Prot Function
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Documents
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Other Versions
SKU Description Size Price
KN513677 Ppargc1b - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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