Mouse Kcnn2 activation kit by CRISPRa

SKU GA212511

Kcnn2 CRISPRa kit - CRISPR gene activation of mouse potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Kcnn2
• Locus ID: 140492
• Components:

  GA212511G1, Kcnn2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA212511G2, Kcnn2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA212511G3, Kcnn2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001312905, NM_080465
• UniProt ID: P58390
• Synonyms: bc; fri; KCa2.2; SK2; SKCA2
• Summary: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.[UniProtKB/Swiss-Prot Function]