Mouse Cyp4v3 activation kit by CRISPRa

SKU GA211697

Cyp4v3 CRISPRa kit - CRISPR gene activation of mouse cytochrome P450, family 4, subfamily v, polypeptide 3

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Cyp4v3
• Locus ID: 102294
• Components:

  GA211697G1, Cyp4v3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA211697G2, Cyp4v3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA211697G3, Cyp4v3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_133969
• UniProt ID: Q9DBW0
• Synonyms: AU043077; AW111961; Cyp4v2
• Summary: Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye. Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate. Also produces some 21-hydroxydocosahexaenoate. Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA).[UniProtKB/Swiss-Prot Function]