Mouse Lrrc19 activation kit by CRISPRa

SKU GA211577

Lrrc19 CRISPRa kit - CRISPR gene activation of mouse leucine rich repeat containing 19

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Lrrc19
• Locus ID: 100061
• Components:

  GA211577G1, Lrrc19 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA211577G2, Lrrc19 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA211577G3, Lrrc19 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_175305, NM_001356281
• UniProt ID: Q8BZT5
• Synonyms: 9130022A01Rik; AI314124; AL022954; AW261791
• Summary: Pathogen-recognition receptor which mediates the activation of TRAF2- and TRAF6 NF-kappa-B signaling pathways and induces the expression of proinflammatory cytokines (PubMed:26776522, PubMed:19679103, PubMed:25026888). In kidney, prevents infection by uropathogenic bacteria by inducing the production of cytokines, chemokines and antimicrobial substances (PubMed:25026888). In gut, involved in host-microbiota interactions, plays a critical role in promoting the recruitment of immune cells and intestinal inflammation (PubMed:26776522).[UniProtKB/Swiss-Prot Function]