Mouse Obsl1 activation kit by CRISPRa

SKU GA211520

Obsl1 CRISPRa kit - CRISPR gene activation of mouse obscurin-like 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Obsl1
• Locus ID: 98733
• Components:

  GA211520G1, Obsl1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA211520G2, Obsl1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA211520G3, Obsl1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001310679, NM_178884
• UniProt ID: D3YYU8
• Synonyms: AW822216
• Summary: Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons (By similarity).[UniProtKB/Swiss-Prot Function]