Mouse Gpr137b activation kit by CRISPRa

SKU GA211265

Gpr137b CRISPRa kit - CRISPR gene activation of mouse G protein-coupled receptor 137B

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Gpr137b
• Locus ID: 83924
• Components:

  GA211265G1, Gpr137b gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA211265G2, Gpr137b gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA211265G3, Gpr137b gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_031999
• UniProt ID: Q8BNQ3
• Synonyms: AI788917; AU016435; AW546472; C80550; C80741; C730041E01; D13Abb1e; Tm7sf1
• Summary: Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy (By similarity). Acts also as a negative regulator of osteoclast activity (PubMed:31173907). Involved in interleukin-4-induced M2 macrophage polarization (PubMed:30595385).[UniProtKB/Swiss-Prot Function]